Table 5 Comparison of the risk profile between patients with developed medication-related osteonecrosis of the jaw (MRONJ) and patients without MRONJ

Gender: n (%)

 Female

46 (92)

12 (100)

0.578

 Male

4 (8)

0

Age: mean (SD)

67.3 (11.61)

68.3 (16.7)

0.363

 ≤ 60: n (%)

13 (26)

3 (25)

1.000

 > 60: n (%)

37 (74)

9 (75)

Primary pathology: n (%)

0.268

 Osteoporosis

23 (46)

2 (16.67)

0.101

 Oncological

13 (26)

5 (41.7)

0.305

 Osteogenesis imperfecta

1 (2)

0

1.000

 Patients with CTIBL

13 (26)

5 (41.67)

0.305

Individual risk assessment: n (%)

0.142

 LD-BMAs

LD-BMAs R₀

5 (13.51)

2 (28.57)

0.307

LD-BMAs R_x

32 (86.49)

5 (71.43)

 HD-BMAs

HD-BMAs R₊

6 (46.15)

1 (20)

0.596

HD-BMAs R₊₊

7 (53.85)

4 (80)

Administrated agent type: n (%)

 Bisphosphonates

32 (64)

8 (66.67)

0.916

 Denosumab

15 (30)

3 (25)

 Both

3 (6)

1 (8.33)

Related drug: n (%)

0.102

 Zoledronic acid

6 (12)

5 (41.67)

0.029

 Alendronic acid

10 (20)

2 (16.67)

1.000

 Ibandronic acid

5 (10)

1 (8.33)

1.000

 Risedronic acid

5 (10)

0

0.573

 Clodronic acid

3 (6)

0

1.000

 Neridronic acid

1 (2)

0

1.000

 Denosumab

15 (30)

2 (16.67)

0.484

 More than one drug

5 (10)

2 (16.67)

0.645

Route of drug administration: n (%)

0.242

 Oral

22 (44)

3 (25)

0.330

 S.Q.

15 (30)

2 (16.67)

0.484

 I.M.

2 (4)

0

1.000

 I.V.

6 (12)

5 (41.67)

0.029

 More than one

5 (10)

2 (16.67)

0.612

Duration of treatment (months): mean (SD)

55.3 (45.7)

46.7 (30.96)

0.796

 ≥ 3 years: n (%)

32 (64)

7 (58.33)

0.748

 < 3 years: n (%)

18 (36)

5 (41.67)

General medical conditions: n (%)

 Bone metastasis

4 (8)

1 (8.33)

1.000

 Diabetes mellitus

4 (8)

3 (25)

0.125

 Thyroid pathology

13 (26)

0

0.055

 Chemotherapy

10 (20)

4 (33.33)

0.442

 Radiotherapy

15 (30)

4 (33.33)

1.000

 Corticosteroids

4 (8)

4 (33.33)

0.039

 Other concomitant pathologies

11 (22)

2 (16.67)

1.000

Tobacco status: n (%)

 Non-smokers

35 (70)

11 (91.67)

0.261

 Ex-smokers

8 (16)

1 (8.33)

 Smokers

7 (14)

0

Tobacco consumption amount (pack years): n (%)

 Ex-smokers

≤ 20 pack years

8 (16)

1 (8.33)

1.000

> 20 pack years

0

0

 Smokers

≤ 20 pack years

4 (8)

0

1.000

> 20 pack years

3 (6)

0

Alcohol status: n (%)

 Non-drinkers

50 (100)

12 (100)

1.000

 Drinkers

0

0

Extraction site: n (%)

0.394

 Maxilla

18 (36)

6 (50)

0.511

 Mandible

19 (38)

5 (41.67)

1.000

 Both

13 (26)

1 (8.33)

0.267

Number of extracted teeth: mean (SD)

2.32 (1.89)

2.3 (2.2)

0.977