Table 1 The effects of IL-6 on dental stem cell behaviours
From: Unravelling the role of interleukin-6 in regulating dental stem cell behaviour: a scoping review
Cell Types | Finding | References |
|---|---|---|
Stem cells isolated from human exfoliated deciduous teeth (SHEDs) | IL-6 treatment promoted pluripotent stem cell marker expression. | Govitvattana et al., 2013 [64]; Govitvattana et al. 2015 [65]; Nowwarote et al., 2017 [66] |
IL-6 promoted mineralization. | Nowwarote et al., 2018 [67] | |
Endothelial cell-secreted IL-6 is involved in the maintenance of the perivascular niche. | Oh et al., 2020 [76] | |
Human dental pulp stem cells (DPSCs) | IL-6 cytokine family promoted osteogenic differentiation. | Park et al. 2019 [70]; Feng et al., 2016 [69]; Kang et al., 2022 [77] |
IL-6 attenuated osteogenic, chondrogenic, and adipogenic differentiation. | Kaplan et al., 2023 [71] | |
IL-6 inhibited neuronal differentiation. | Park et al. 2019 [70] | |
IL-6 released by human dental pulp stem cells promoted M2 macrophage polarization. | Liu et al., 2023 [75] | |
Endothelial cell-secreted IL-6 is involved in the maintenance of the perivascular niche. | Oh et al., 2020 [76] | |
Human periodontal ligament stem cells (PDLSCs) | IL-6 promoted osteogenic differentiation. | Purwaningrum et al., 2023 [68] |
IL-6 released by mechanically loaded human periodontal ligament stem cells promoted osteoclast formation. | Luo et al., 2024 [78] | |
IL-6 participated in D-mannose-enhanced immunomodulation. | Guo et al., 2018 [79] | |
IL-6 released by human periodontal ligament stem cells reduced polymorphonuclear neutrophil apoptosis | Wang et al., 2017 [80] |